Ultrastructural Aspects of Apoptosis in Systemic Sclerosis Inflammatory Myopathy

Rituximab-induced neutropenia in a patient with inflammatory myopathy and systemic sclerosis overlap disease

Rituximab (RTX) is a monoclonal chimeric antibody directed against the CD20 antigen of B lymphocytes. Late onset neutropenia (LON) is a recognised complication of rituximab usually occurring 4 weeks after the last dose and is reported in both haematological and rheumatological conditions. However, it has never been described in a patient with myositis and systemic sclerosis overlap disease. We ...

Apoptosis of T Lymphocytes in Systemic Sclerosis

Aldolase predicts subsequent myopathy occurrence in systemic sclerosis

INTRODUCTION Myopathy related to systemic sclerosis (Myo-SSc) is a disabling and unpredictable complication of SSc. We assessed the predictive value of serum aldolase, creatine kinase (CK), alanine transaminase (ALT), aspartate transaminase (AST) and C-reactive protein (CRP) to estimate the risk of developing Myo-SSc. METHODS We enrolled 137 SSc patients without proximal muscle weakness in a ...

Clinical aspects of systemic sclerosis (scleroderma).

Systemic sclerosis (scleroderma) is a disease of unknown cause, the hallmark of which is induration of the skin. Although long regarded as a bland fibrotic process, there is now ample evidence of an active inflammatory process underlying thepathogenesis ofsystemic sclerosis. In addition, microvascular disease and immunological abnormalities are present in most cases. It remains to be determined...

Gastric Strongyloides Stercoralis in a Patient with Inflammatory Myopathy

Strongyloides stercoralis is a free living tropical and semitropical soil nematode which its larva penetrates skin. It can complete its life cycle in human body and causes autoinfection. Most patients have no frank symptoms. But respiratory, gastrointestinal and skin manifestation may occur. We report a 76 year old man admitted to emergency room with muscle weakness, dyspnea, nausea, v...